Catalytic tetrahydropyranylation of phenols and alcohols using vanadium(V)-substituted polyoxomolybdates

Abstract

Alcohols and phenols were tetrahydropyranylated in the presence of H7[PMo8V4O40] in good to excellent yields in acetonitrile and under solventfree reaction conditions. A mild and convenient method for the formation and deprotection of tetrahydropyranyl ethers (THP ethers) is described. The formation of THP ethers from the corresponding alcohols was accomplished in the presence of acid-sensitive functional groups.

Keywords

• THP ether
• heteropolyacid
• protecting group
• tetrahydropyranylation
• detetrahydropyranylation