Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release

Yasuhiko Orita; Susumu Shimanuki; Satoshi Okada; Kentaro Nakamura; Hiroyuki Nakamura; Yoshitaka Kitamoto; Yusuke Shimoyama; Yuta Kurashina

Ultrasonics Sonochemistry (Mar 2023)

Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release

Yasuhiko Orita,
Susumu Shimanuki,
Satoshi Okada,
Kentaro Nakamura,
Hiroyuki Nakamura,
Yoshitaka Kitamoto,
Yusuke Shimoyama,
Yuta Kurashina

Affiliations

Yasuhiko Orita: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-Ku, Tokyo 152-8550, Japan
Susumu Shimanuki: Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-Ku, Yokohama 226-8503, Japan
Satoshi Okada: Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori- Ku, Yokohama 226-8503, Japan
Kentaro Nakamura: Laboratory for Future Interdisciplinary Research of Science and Technology, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori- Ku, Yokohama 226-8503, Japan
Hiroyuki Nakamura: Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori- Ku, Yokohama 226-8503, Japan
Yoshitaka Kitamoto: Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-Ku, Yokohama 226-8503, Japan
Yusuke Shimoyama: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-Ku, Tokyo 152-8550, Japan
Yuta Kurashina: Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-Ku, Yokohama 226-8503, Japan; Division of Advanced Mechanical Systems Engineering, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei-Shi, Tokyo 184-8588, Japan; Corresponding author at: Division of Advanced Mechanical Systems Engineering, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei-shi, Tokyo 184-8588, Japan.

Journal volume & issue: Vol. 94
p. 106326

Abstract

Read online

The role of liposomes as drug carriers has been investigated. Ultrasound-based drug release methods have been developed for on-demand drug delivery. However, the acoustic responses of current liposome carriers result in low drug release efficiency. In this study, CO2-loaded liposomes were synthesized under high pressure from supercritical CO2 and irradiated with ultrasound at 237 kHz to demonstrate their superior acoustic responsiveness. When liposomes containing fluorescent drug models were irradiated with ultrasound under acoustic pressure conditions that are safe for the human body, CO2-loaded liposomes synthesized using supercritical CO2 had 17.1 times higher release efficiency than liposomes synthesized using the conventional Bangham method. In particular, the release efficiency of CO2-loaded liposomes synthesized using supercritical CO2 and monoethanolamine was 19.8 times higher than liposomes synthesized using the conventional Bangham method. These findings on the release efficiency of acoustic-responsive liposomes suggest an alternative liposome synthesis strategy for on-demand release of drugs by ultrasound irradiation in future therapies.

Published in Ultrasonics Sonochemistry

ISSN: 1350-4177 (Print); 1873-2828 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry; Science: Physics: Acoustics. Sound
Website: https://www.journals.elsevier.com/ultrasonics-sonochemistry

About the journal

Abstract

Keywords