Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes
Amal El Mahdaoui,
Smaail Radi,
Youssef Draoui,
Mohamed El Massaoudi,
Sabir Ouahhoud,
Abdeslam Asehraou,
Nour Eddine Bentouhami,
Ennouamane Saalaoui,
Redouane Benabbes,
Koen Robeyns,
Yann Garcia
Affiliations
Amal El Mahdaoui
LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Smaail Radi
LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Youssef Draoui
LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Mohamed El Massaoudi
LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Sabir Ouahhoud
Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Abdeslam Asehraou
Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Nour Eddine Bentouhami
Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Ennouamane Saalaoui
Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Redouane Benabbes
Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco
Koen Robeyns
Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium
Yann Garcia
Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium
In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.
