Impact of Postresuscitative Endogenous Intoxication on Lipid Peroxidation Processes in the Experiment

Abstract

Endogenous intoxication and free radical oxidation were studied in rats after 10-minute clinical death due to systemic circulatory arrest. There were qualitative and quantitative changes in toxic substances throughout a 35-day postresuscitative period, as well as increased free radical oxidation processes in the vital organs (brain, liver, kidneys). At the same time, plasma samples showed inhibited chemiluminescence along with the elevated levels of low and medium molecular-weight substances since medium-weight molecules bound ferrous iron ions that were added to induce luminescence. The chemilu-minescence technique may serve as a rapid method for evaluating the degree of endogenous intoxication.

Keywords

• endogenous intoxication
• postresuscitative period
• chemiluminescence