Jichu yixue yu linchuang (Mar 2024)

Research progress on the mechanism of annexin A family members in breast cancer

  • NAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan

DOI
https://doi.org/10.16352/j.issn.1001-6325.2024.03.0393
Journal volume & issue
Vol. 44, no. 3
pp. 393 – 397

Abstract

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The annexins(ANX) family is widely present in the cell membrane, cytoplasm or extracellular matrix. As key tumor regulatory molecules, annexins A (ANX A) family can promote or inhibit invasion and metastasis of breast cancer cells by influencing cell membrane and cytoskeleton formation and participating in signaling pathways. ANX A family also plays a role in the apoptosis of breast cancer cells by regulation of pro-apoptotic proteins and cell cycle independent kinases (CDKs) and related pathways. In addition, ANX A family can also promote therapeutic resistance to a large number of drugs. For instance,ANX A1 enhances triple-negative breast cancer resistance by inducing epithelial-mesenchymal transformation. ANX A4 induces resistance by forming ANX A4-Fhit complexes and secretion of exosomes containing ANX A6 promotes paclitaxel resistance in breast cancer cells in a YAP1-dependent manner. So ANX A family may be a new target for breast cancer treatment.

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