Hypertension in Pregnancy (Apr 2021)

Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia

  • Petar Cabunac,
  • Nataša Karadžov Orlić,
  • Daniela Ardalić,
  • Gorica Banjac,
  • Jasmina Ivanišević,
  • Jelena Janać,
  • Jelena Vekić,
  • Aleksandra Zeljković,
  • Marija Mihajlović,
  • Nina Rajović,
  • Nataša Milić,
  • Željko Miković

DOI
https://doi.org/10.1080/10641955.2021.1921790
Journal volume & issue
Vol. 40, no. 2
pp. 162 – 170

Abstract

Read online

OBJECTIVE: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia. METHODS: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy. RESULTS: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05). CONCLUSION: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.

Keywords