Ultrastructural changes in the cells of antral gastric mucosa in patients with duodenal ulcer on melatonin treatment

Abstract

Aim. To study ultrastructural condition of the eels in antral gastric mucosa in patients with duodenal ulcer on melatonin treatment. Material and methods. Electron microscopy was made of biopsy specimens of antral stomach mucosa obtained from 14 patients with duodenal ulcer (DU) in exacerbation and in clinicoendoscopic remission after therapy with proton pump blockers (group I) and after this therapy combined mth melatonin (group 2). Results. In patients of group 2 there was an increased number of differentiated cover and principal cells, moderately differentiated parietal cells predominated. Conclusion. Melatonin is one of the drugs potentiating trophic processes in gastric mucosa.

Keywords

• duodenal ulcer
• melatonin
• treatment