Research advances on the age-related macular degeneration

Abstract

Age-related macular degeneration(AMD) is a serious threat to the visual health of the elderly, and the dysfunction of retinal pigment epithelial cells(RPE) is a significant etiology risk. Aging process leads to RPE replication senescence, and some environment factors like light exposure and cigarette exposure may lead to RPE stress premature aging, and the decreased lysosomal digestion ability of senescent RPE cells may lead to the accumulation of lipofuscin, triggering the occurrence of early AMD. A series of homeostatic imbalances in aging retina, such as cell senescence-renewal imbalance, oxidative stress-antioxidant imbalance, chronic inflammatory-anti-inflammatory imbalance, intestinal barrier and intestinal microbiota imbalance and pro-angiogenesis-antiangiogenic imbalance all contribute to the development of AMD.

Keywords

• age-related macular degeneration(amd)|retina|retinal pigment epithelial cells(rpe)|cellular senescence