γδ T cells control humoral immune response by inducing T follicular helper cell differentiation

Rafael M. Rezende; Amanda J. Lanser; Stephen Rubino; Chantal Kuhn; Nathaniel Skillin; Thais G. Moreira; Shirong Liu; Galina Gabriely; Bruna A. David; Gustavo B. Menezes; Howard L. Weiner

doi:10.1038/s41467-018-05487-9

Nature Communications (Aug 2018)

γδ T cells control humoral immune response by inducing T follicular helper cell differentiation

Rafael M. Rezende,
Amanda J. Lanser,
Stephen Rubino,
Chantal Kuhn,
Nathaniel Skillin,
Thais G. Moreira,
Shirong Liu,
Galina Gabriely,
Bruna A. David,
Gustavo B. Menezes,
Howard L. Weiner

Affiliations

Rafael M. Rezende: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Amanda J. Lanser: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Stephen Rubino: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Chantal Kuhn: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Nathaniel Skillin: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Thais G. Moreira: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Shirong Liu: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Galina Gabriely: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Bruna A. David: Center for Gastrointestinal Biology, Federal University of Minas Gerais
Gustavo B. Menezes: Center for Gastrointestinal Biology, Federal University of Minas Gerais
Howard L. Weiner: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-05487-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Many immune functions have been reported for γδ T cells, including the regulation of antibody responses. Here the authors show that CXCR5+ γδ T cells release Wnt ligands to initiate the T follicular helper cell differentiation program and promote antibody production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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