Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
Tsung-Hung Chen,
Wu-Fu Chen,
Zhi-Hong Wen,
Mei-Chin Lu,
Wei-Hsien Wang,
Jan-Jung Li,
Yang-Chang Wu,
Ping-Jyun Sung
Affiliations
Tsung-Hung Chen
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Wu-Fu Chen
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Mei-Chin Lu
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Wei-Hsien Wang
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Jan-Jung Li
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Yang-Chang Wu
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Ping-Jyun Sung
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
