High Frequency of Viral Co-Detections in Acute Bronchiolitis
Hortense Petat,
Vincent Gajdos,
François Angoulvant,
Pierre-Olivier Vidalain,
Sandrine Corbet,
Christophe Marguet,
Jacques Brouard,
Astrid Vabret,
Meriadeg Ar Gouilh
Affiliations
Hortense Petat
Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN, UNIROUEN, EA2656, F-14033 Caen, France
Vincent Gajdos
Antoine Béclère University Hospital, APHP, 92140 Clamart, France
François Angoulvant
Assistance Publique-Hôpitaux de Paris, Paediatric Emergency Department, Necker-Enfants Malades University Hospital, Université de Paris, 75015 Paris, France
Pierre-Olivier Vidalain
Equipe Chimie et Biologie, Modélisation et Immunologie Pour la Thérapie (CBMIT), Université Paris Descartes, CNRS UMR 8601, 75006 Paris, France
Sandrine Corbet
Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN, UNIROUEN, EA2656, F-14033 Caen, France
Christophe Marguet
Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN, UNIROUEN, EA2656, F-14033 Caen, France
Jacques Brouard
Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN, UNIROUEN, EA2656, F-14033 Caen, France
Astrid Vabret
Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN, UNIROUEN, EA2656, F-14033 Caen, France
Meriadeg Ar Gouilh
Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0), Normandie University, UNICAEN, UNIROUEN, EA2656, F-14033 Caen, France
Over two years (2012–2014), 719 nasopharyngeal samples were collected from 6-week- to 12-month-old infants presenting at the emergency department with moderate to severe acute bronchiolitis. Viral testing was performed, and we found that 98% of samples were positive, including 90% for respiratory syncytial virus, 34% for human rhino virus, and 55% for viral co-detections, with a predominance of RSV/HRV co-infections (30%). Interestingly, we found that the risk of being infected by HRV is higher in the absence of RSV, suggesting interferences or exclusion mechanisms between these two viruses. Conversely, coronavirus infection had no impact on the likelihood of co-infection involving HRV and RSV. Bronchiolitis is the leading cause of hospitalizations in infants before 12 months of age, and many questions about its role in later chronic respiratory diseases (asthma and chronic obstructive pulmonary disease) exist. The role of virus detection and the burden of viral codetections need to be further explored, in order to understand the physiopathology of chronic respiratory diseases, a major public health issue.
