Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration

Bin Yu; Ziqi Zhu; Tao Hu; Jiawei Lu; Beiduo Shen; Tongde Wu; Kai Guo; Surendra Kumar Chaudhary; Hang Feng; Weidong Zhao; Desheng Wu

doi:10.1186/s12891-022-05579-0

BMC Musculoskeletal Disorders (Jul 2022)

Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration

Bin Yu,
Ziqi Zhu,
Tao Hu,
Jiawei Lu,
Beiduo Shen,
Tongde Wu,
Kai Guo,
Surendra Kumar Chaudhary,
Hang Feng,
Weidong Zhao,
Desheng Wu

Affiliations

Bin Yu: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Ziqi Zhu: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Tao Hu: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Jiawei Lu: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Beiduo Shen: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Tongde Wu: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Kai Guo: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Surendra Kumar Chaudhary: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Hang Feng: Department of Surgery of Spine and Spinal Cord, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
Weidong Zhao: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University
Desheng Wu: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University

DOI: https://doi.org/10.1186/s12891-022-05579-0
Journal volume & issue: Vol. 23, no. 1
pp. 1 – 12

Abstract

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Highlights 1. An IDD-related ceRNA network involving four circRNAs, three miRNAs and 11 mRNAs was constructed. 2. The expression levels of miR-185-5p, miR-486-5p, FOXO1, SMAD2 and TGFB1 were consistent in different databases. 3. Our study identified IDD-related circRNA–miRNA–mRNA interaction axes, including circRNA_100086–miR-509-3p–MAPK1.

Published in BMC Musculoskeletal Disorders

ISSN: 1471-2474 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system
Website: http://bmcmusculoskeletdisord.biomedcentral.com

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Abstract

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