Review on cumulative exposure risk assessment model and method of combined action of chemical mixtures at home and abroad

Abstract

The combined effects of human exposure to chemical mixtures have attracted the attention of government agencies in many countries. Many institutions have carried out a lot of research on the cumulative exposure assessment of the combined effects of chemical mixtures. This article outlines the principles and standards for grouping chemicals with a common action mechanism in the cumulative exposure risk assessment of chemicals, and based on the types of combined effects of chemicals and their judgment method, expounds the Hazard Index method, Cumulative Risk Index method, Relative Potency Factor method, Point of Departure method, combined Margin of Exposure method, reaction addition method based on independent reaction, and hazard index correction method based on interaction, etc. In addition, in the exposure assessment of compound mixtures, the accuracy of physiologically-based toxicokinetic model method and conventional assessment method are analyzed, and a new direction for exploration is proposed for more accurate and scientific assessments in China in the future.

Keywords

• chemical mixture
• combined effect
• cumulative exposure
• risk assessment