Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Ming-liang Ji; Hua Jiang; Xue-jun Zhang; Pei-liang Shi; Chao Li; Hao Wu; Xiao-tao Wu; Yun-tao Wang; Chen Wang; Jun Lu

doi:10.1038/s41467-018-07360-1

Nature Communications (Nov 2018)

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Ming-liang Ji,
Hua Jiang,
Xue-jun Zhang,
Pei-liang Shi,
Chao Li,
Hao Wu,
Xiao-tao Wu,
Yun-tao Wang,
Chen Wang,
Jun Lu

Affiliations

Ming-liang Ji: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Hua Jiang: Department of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University
Xue-jun Zhang: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Pei-liang Shi: Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Collaborative Innovation Center of Genetics and Development, Nanjing University
Chao Li: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Hao Wu: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Xiao-tao Wu: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Yun-tao Wang: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Chen Wang: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University
Jun Lu: Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University

DOI: https://doi.org/10.1038/s41467-018-07360-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-coupled miR-141 into the NP alleviates IDD in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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