BMC Research Notes (May 2022)

Mitral regurgitation quantified by CMR 4D-flow is associated with microvascular obstruction post reperfused ST-segment elevation myocardial infarction

  • Hosamadin Assadi,
  • Ciaran Grafton-Clarke,
  • Ahmet Demirkiran,
  • Rob J. van der Geest,
  • Robin Nijveldt,
  • Marcus Flather,
  • Andrew J. Swift,
  • Vass S. Vassiliou,
  • Peter P. Swoboda,
  • Amardeep Dastidar,
  • John P. Greenwood,
  • Sven Plein,
  • Pankaj Garg

DOI
https://doi.org/10.1186/s13104-022-06063-7
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 7

Abstract

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Abstract Objectives Mitral regurgitation (MR) and microvascular obstruction (MVO) are common complications of myocardial infarction (MI). This study aimed to investigate the association between MR in ST-elevation MI (STEMI) subjects with MVO post-reperfusion. STEMI subjects undergoing primary percutaneous intervention were enrolled. Cardiovascular magnetic resonance (CMR) imaging was performed within 48-hours of initial presentation. 4D flow images of CMR were analysed using a retrospective valve tracking technique to quantify MR volume, and late gadolinium enhancement images of CMR to assess MVO. Results Among 69 patients in the study cohort, 41 had MVO (59%). Patients with MVO had lower left ventricular (LV) ejection fraction (EF) (42 ± 10% vs. 52 ± 8%, P 2.5 ml. We conclude that in patients with reperfused STEMI, the degree of acute MR is associated with the degree of MVO.

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