Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

Jinsheng Wen; Annie Elong Ngono; Jose Angel Regla-Nava; Kenneth Kim; Matthew J. Gorman; Michael S. Diamond; Sujan Shresta

doi:10.1038/s41467-017-01669-z

Nature Communications (Nov 2017)

Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

Jinsheng Wen,
Annie Elong Ngono,
Jose Angel Regla-Nava,
Kenneth Kim,
Matthew J. Gorman,
Michael S. Diamond,
Sujan Shresta

Affiliations

Jinsheng Wen: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Annie Elong Ngono: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Jose Angel Regla-Nava: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Kenneth Kim: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
Matthew J. Gorman: Department of Medicine, Molecular Microbiology, Pathology and Immunology, The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine
Michael S. Diamond: Department of Medicine, Molecular Microbiology, Pathology and Immunology, The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine
Sujan Shresta: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology

DOI: https://doi.org/10.1038/s41467-017-01669-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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