Nature Communications (Sep 2019)
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
- Xavier Hadoux,
- Flora Hui,
- Jeremiah K. H. Lim,
- Colin L. Masters,
- Alice Pébay,
- Sophie Chevalier,
- Jason Ha,
- Samantha Loi,
- Christopher J. Fowler,
- Christopher Rowe,
- Victor L. Villemagne,
- Edward N. Taylor,
- Christopher Fluke,
- Jean-Paul Soucy,
- Frédéric Lesage,
- Jean-Philippe Sylvestre,
- Pedro Rosa-Neto,
- Sulantha Mathotaarachchi,
- Serge Gauthier,
- Ziad S. Nasreddine,
- Jean Daniel Arbour,
- Marc-André Rhéaume,
- Sylvain Beaulieu,
- Mohamed Dirani,
- Christine T. O. Nguyen,
- Bang V. Bui,
- Robert Williamson,
- Jonathan G. Crowston,
- Peter van Wijngaarden
Affiliations
- Xavier Hadoux
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Flora Hui
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Jeremiah K. H. Lim
- Department of Optometry and Vision Sciences, University of Melbourne
- Colin L. Masters
- The Florey Institute, The University of Melbourne
- Alice Pébay
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Sophie Chevalier
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Jason Ha
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Samantha Loi
- Neuropsychiatry Unit, North Western Mental Health, Melbourne Health, Royal Melbourne Hospital
- Christopher J. Fowler
- The Florey Institute, The University of Melbourne
- Christopher Rowe
- Austin Health
- Victor L. Villemagne
- Austin Health
- Edward N. Taylor
- Centre for Astrophysics and Supercomputing, Swinburne University of Technology
- Christopher Fluke
- OzGrav-Swinburne, Centre for Astrophysics & Supercomputing, Swinburne University of Technology
- Jean-Paul Soucy
- McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
- Frédéric Lesage
- École Polytechnique de Montréal, Institut de génie biomédical, Département de Génie électrique
- Jean-Philippe Sylvestre
- Optina Diagnostics
- Pedro Rosa-Neto
- McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
- Sulantha Mathotaarachchi
- McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
- Serge Gauthier
- Alzheimer’s Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University
- Ziad S. Nasreddine
- MoCA Clinic and Institute
- Jean Daniel Arbour
- Clinique ophtalmologique 2121
- Marc-André Rhéaume
- Clinique ophtalmologique 2121
- Sylvain Beaulieu
- Département de médecine nucléaire, Hôpital Maisonneuve-Rosemont
- Mohamed Dirani
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Christine T. O. Nguyen
- Department of Optometry and Vision Sciences, University of Melbourne
- Bang V. Bui
- Department of Optometry and Vision Sciences, University of Melbourne
- Robert Williamson
- Murdoch Children’s Research Institute and Department of Paediatrics, University of Melbourne
- Jonathan G. Crowston
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Peter van Wijngaarden
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- DOI
- https://doi.org/10.1038/s41467-019-12242-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ.
