Nature Communications (Nov 2022)
Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice
- Xuanchun Wang,
- Yanliang Li,
- Guifen Qiang,
- Kaihua Wang,
- Jiarong Dai,
- Maximilian McCann,
- Marcos D. Munoz,
- Victoria Gil,
- Yifei Yu,
- Shengxian Li,
- Zhihong Yang,
- Shanshan Xu,
- Jose Cordoba-Chacon,
- Dario F. De Jesus,
- Bei Sun,
- Kuangyang Chen,
- Yahao Wang,
- Xiaoxia Liu,
- Qing Miao,
- Linuo Zhou,
- Renming Hu,
- Qiang Ding,
- Rohit N. Kulkarni,
- Daming Gao,
- Matthias Blüher,
- Chong Wee Liew
Affiliations
- Xuanchun Wang
- Department of Endocrinology, Huashan Hospital, Fudan University
- Yanliang Li
- Department of Endocrinology, Huashan Hospital, Fudan University
- Guifen Qiang
- Department of Physiology & Biophysics, University of Illinois at Chicago
- Kaihua Wang
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
- Jiarong Dai
- Department of Endocrinology, Huashan Hospital, Fudan University
- Maximilian McCann
- Department of Physiology & Biophysics, University of Illinois at Chicago
- Marcos D. Munoz
- Department of Physiology & Biophysics, University of Illinois at Chicago
- Victoria Gil
- Department of Physiology & Biophysics, University of Illinois at Chicago
- Yifei Yu
- Department of Endocrinology, Huashan Hospital, Fudan University
- Shengxian Li
- Department of Physiology & Biophysics, University of Illinois at Chicago
- Zhihong Yang
- Research Division, Joslin Diabetes Center, Harvard Medical School
- Shanshan Xu
- Department of Physiology & Biophysics, University of Illinois at Chicago
- Jose Cordoba-Chacon
- Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago
- Dario F. De Jesus
- Research Division, Joslin Diabetes Center, Harvard Medical School
- Bei Sun
- NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University
- Kuangyang Chen
- Department of Endocrinology, Huashan Hospital, Fudan University
- Yahao Wang
- Department of Endocrinology, Huashan Hospital, Fudan University
- Xiaoxia Liu
- Department of Endocrinology, Huashan Hospital, Fudan University
- Qing Miao
- Department of Endocrinology, Huashan Hospital, Fudan University
- Linuo Zhou
- Department of Endocrinology, Huashan Hospital, Fudan University
- Renming Hu
- Department of Endocrinology, Huashan Hospital, Fudan University
- Qiang Ding
- Department of Urology, Huashan Hospital, Fudan University
- Rohit N. Kulkarni
- Research Division, Joslin Diabetes Center, Harvard Medical School
- Daming Gao
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
- Matthias Blüher
- Department of Medicine, University of Leipzig
- Chong Wee Liew
- Department of Physiology & Biophysics, University of Illinois at Chicago
- DOI
- https://doi.org/10.1038/s41467-022-34259-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a secreted protein of incompletely understood physiological function. Here the authors show that scEMC10 is upregulated in people with obesity, and that that genetic EMC10 deletion or antibody-based neutralization of EMC10 prevents diet-induced obesity in mice.
