Communications Biology (May 2021)
CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
- Yo-Ping Lai,
- Lu-Cheng Kuo,
- Been-Ren Lin,
- Hung-Ju Lin,
- Chih-Yu Lin,
- Yi-Ting Chen,
- Pei-Wen Hsiao,
- Huan-Tsung Chang,
- Patrick Chow-In Ko,
- Hsiao-Chin Chen,
- Hsiang-Yu Chang,
- Jean Lu,
- Hong-Nerng Ho,
- Betty A. Wu-Hsieh,
- John T. Kung,
- Shu-Ching Chen
Affiliations
- Yo-Ping Lai
- Department of Internal Medicine, National Taiwan University Hospital
- Lu-Cheng Kuo
- Department of Internal Medicine, National Taiwan University Hospital
- Been-Ren Lin
- Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine
- Hung-Ju Lin
- Department of Internal Medicine, National Taiwan University Hospital
- Chih-Yu Lin
- Agricultural Biotechnology Research Center, Academia Sinica
- Yi-Ting Chen
- Institute of Molecular Biology, Academia Sinica
- Pei-Wen Hsiao
- Agricultural Biotechnology Research Center, Academia Sinica
- Huan-Tsung Chang
- Department of Chemistry, National Taiwan University
- Patrick Chow-In Ko
- Department of Emergency Medicine, National Taiwan University Hospital
- Hsiao-Chin Chen
- Department of Medical Research, National Taiwan University Hospital
- Hsiang-Yu Chang
- Department of Chemistry, National Taiwan University
- Jean Lu
- Genomics Research Center, Academia Sinica
- Hong-Nerng Ho
- Department of Obstetrics and Gynecology, National Taiwan University, College of Medicine
- Betty A. Wu-Hsieh
- Graduate Institute of Immunology, National Taiwan University, College of Medicine
- John T. Kung
- Institute of Molecular Biology, Academia Sinica
- Shu-Ching Chen
- Department of Medical Research, National Taiwan University Hospital
- DOI
- https://doi.org/10.1038/s42003-021-02119-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 12
Abstract
Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.
