Nature Communications (Jul 2018)

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

  • Sunglim Cho,
  • Hyang-Mi Lee,
  • I-Shing Yu,
  • Youn Soo Choi,
  • Hsi-Yuan Huang,
  • Somaye Sadat Hashemifar,
  • Ling-Li Lin,
  • Mei-Chi Chen,
  • Nikita D. Afanasiev,
  • Aly Azeem Khan,
  • Shu-Wha Lin,
  • Alexander Y. Rudensky,
  • Shane Crotty,
  • Li-Fan Lu

DOI
https://doi.org/10.1038/s41467-018-05196-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating intricate controls of GC response by miR-146.