Clinico-anamnestic and immunological characteristics of premature infants with respiratory distress syndrome

Abstract

Purpose of the study: compare perinatal factors, clinical-anamnestic data and the levels of anti-inflammatory IL-10 and indirect marker of fibrosis - metalloproteinase 3 (MMP3) in preterm infants with and without respiratory distress syndrome (RDS) to clarify their role in the pathogenesis of lung injury during the period from 3 to 6 weeks of life.Patients and methods: 15 premature infants with RDS (group 1) and 10 premature infants without RDS (group 2) were examined in the same period of life.Results: The proportion of children with reduced IL-10 was 60% in group 1 compared to 20% in group 2 (p = 0.048). The proportions of children with reduced MMP3 were 47 and 27%, respectively (p = 0.17). The proportions of elevated IL-10 and MMP3 values were comparable in the two groups (27 and 20% for IL-10 and 13 and 10% for MMP3), the data was unreliable. Children with elevated IL-10 in combination with decreased MMP3 had a history of frequent ARVI complicated by obstructive bronchitis and pneumonia in the first year of life.Conclusion: Premature infants with RDS are characterized by reduced levels of IL-10 and MMP3 compared with the same biomarkers for premature infants without RDS.

Keywords

• rds
• interleukin-10
• mmp3
• premature infants