International Journal of Nanomedicine (Mar 2020)
Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
Abstract
Nina Wijiani, Dewi Isadiartuti, M Agus Syamsur Rijal, Helmy Yusuf Department of Pharmaceutics, Universitas Airlangga, Surabaya, IndonesiaCorrespondence: Helmy YusufDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, IndonesiaTel +62 31 5933150Fax +62 31 5935249Email [email protected]: Curcumin faces a major challenge in clinical use due to its poor aqueous solubility, which affects its bioavailability over oral use. The present study was carried out to overcome this problem.Methods: An amorphous micellar curcumin-spray dried powder (MC-SDP) with self-assembled casein was prepared by the addition of sucrose as a protectant. The dry powder of curcumin-loaded micelles was obtained by a spray-drying technique in the presence of sucrose as a protectant. The MC-SDP in the form of dry powder was further developed into tablets to investigate the dissolution profile. The physical properties of preformed powder were characterized by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Quantitative analysis in the form of solutions was analyzed by high-performance liquid chromatography (HPLC).Results: The physical properties demonstrated that MC-SDP varies from dented to smoother surfaces as a function of sucrose. Furthermore, melting transitions of curcumin in the form of MC-SDP were broadened in all sample mixtures, as observed in the DTA thermogram. The XRD spectra showed that the sharp and very intense peaks of single curcumin crystalline structure no longer existed in all MC-SDP forms, indicating that the mixtures were amorphous. Moreover, a further dissolution study of MC-SDP showed a significant increase of drug dissolved with the presence of sucrose, where > 80% of curcumin from MC-SDP was dissolved within 30 min.Conclusion: The study demonstrated the manufacture of micellar spray-dried powder that would contribute to the development of oral delivery of curcumin.Keywords: micellar, amorphous, crystalline, solid dispersion, dissolution, powder
