Chemical constituents and cytotoxic effects of the essential oil from the root of Cyperus kyllingia Endl.

Abstract

The chemical constituents of the essential oil from the root of Cyperus kyllingia Endl. were obtained from hydrodistillation and subsequently analyzed by a gas chromatography/mass spectrometry (GC-MS) technique. Twenty-eight compounds were identified, accounting for 89.62% of the total oil that consisted mainly of oxygenated sesquiterpenes (50.21%) and sesquiterpene hydrocarbons (38.08%). α-Cadinol (18.62%), caryophyllene oxide (12.18%), α-muurolol (11.56%), Cyperene (10.15%), and α-Cyperone (5.72%) were identified as the major components. The essential oil showed significantl cytotoxicity against NCI-H187, and MCF-7 cell lines with IC50 values of 6.7 and 13.3 µg/mL, and was non-cytotoxic against Vero cells. Furth

Keywords

• cyperus kyllingia endl.
• essential oil
• anticancer activity
• cytotoxicity
• anti-tb activities