A comprehensive review of cellular stress response pathway system of Rhizoma coptidis

Abstract

Introduction: Cellular stress responses play a crucial role in maintaining cellular homeostasis and combating various pathological conditions. Understanding the stress response mechanisms triggered by R. coptidis is critical for harnessing its therapeutic potential. This herb is widely used, but the precise cellular mechanisms through which it exerts its therapeutic effects remain less explored. This review aims to elucidate how R. coptidis affects key cellular pathways and its potential as a therapeutic agent. Method: This review examines existing evidence on the cellular mechanisms and stress response pathways influenced by R. coptidis. The analysis focuses on the regulation of NF-κB, MAPK, PI3K-Akt, AMPK, ERS, and oxidative stress pathways. Sources include peer-reviewed articles, clinical studies, and traditional Chinese medicine (TCM) literature. Results: Evidence indicates that R. coptidis exerts beneficial effects on various diseases by modulating the NF-κB, MAPK, PI3K-Akt, AMPK, ERS, and oxidative stress pathways. By targeting these pivotal pathways, R. coptidis mitigates cellular damage and restores homeostasis under pathological conditions. Conclusion: Understanding the cellular stress response and molecular mechanisms of R. coptidis highlights its multifaceted therapeutic potential. These findings underscore the importance of integrating TCM approaches into modern therapeutic strategies for combating complex diseases. Further investigations into the molecular targets and clinical efficacy of R. coptidis are needed to fully realize its therapeutic potential.

Keywords

• Rhizoma coptidis
• Traditional Chinese medicine
• Therapeutic implications
• NF-κB pathway
• MAPK signalling, antioxidant defence