GTP-State-Selective Cyclic Peptide Ligands of K‑Ras(G12D) Block Its Interaction with Raf

• Ziyang Zhang,
• Rong Gao,
• Qi Hu,
• Hayden Peacock,
• D. Matthew Peacock,
• Shizhong Dai,
• Kevan M. Shokat,
• Hiroaki Suga

Affiliations

Ziyang Zhang

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of CaliforniaSan Francisco, San Francisco, California, United States

Rong Gao

Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan

Qi Hu

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of CaliforniaSan Francisco, San Francisco, California, United States

Hayden Peacock

Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan

D. Matthew Peacock

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of CaliforniaSan Francisco, San Francisco, California, United States

Shizhong Dai

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of CaliforniaSan Francisco, San Francisco, California, United States

Kevan M. Shokat

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of CaliforniaSan Francisco, San Francisco, California, United States

Hiroaki Suga

Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan