Signatures of T cell immunity revealed using sequence similarity with TCRDivER algorithm

Milena Vujović; Paolo Marcatili; Benny Chain; Joseph Kaplinsky; Thomas Lars Andresen

doi:10.1038/s42003-023-04702-8

Communications Biology (Mar 2023)

Signatures of T cell immunity revealed using sequence similarity with TCRDivER algorithm

Milena Vujović,
Paolo Marcatili,
Benny Chain,
Joseph Kaplinsky,
Thomas Lars Andresen

Affiliations

Milena Vujović: DTU HealthTech, Department of Health Technology, Technical University of Denmark
Paolo Marcatili: DTU HealthTech, Department of Health Technology, Technical University of Denmark
Benny Chain: UCL Division of Infection and Immunity, University College London
Joseph Kaplinsky: Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Medicine
Thomas Lars Andresen: DTU HealthTech, Department of Health Technology, Technical University of Denmark

DOI: https://doi.org/10.1038/s42003-023-04702-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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The TCRDivER algorithm incorporates both clone size and sequence similarity of T cell receptors (TCR) to reveal greater complexity in TCR repertoires and novel TCR repertoire traits due to a nonlinear correlation of the two.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal