Transcription coordinates histone amounts and genome content

Kora-Lee Claude; Daniela Bureik; Dimitra Chatzitheodoridou; Petia Adarska; Abhyudai Singh; Kurt M. Schmoller

doi:10.1038/s41467-021-24451-8

Nature Communications (Jul 2021)

Transcription coordinates histone amounts and genome content

Kora-Lee Claude,
Daniela Bureik,
Dimitra Chatzitheodoridou,
Petia Adarska,
Abhyudai Singh,
Kurt M. Schmoller

Affiliations

Kora-Lee Claude: Institute of Functional Epigenetics, Helmholtz Zentrum München
Daniela Bureik: Institute of Functional Epigenetics, Helmholtz Zentrum München
Dimitra Chatzitheodoridou: Institute of Functional Epigenetics, Helmholtz Zentrum München
Petia Adarska: Institute of Functional Epigenetics, Helmholtz Zentrum München
Abhyudai Singh: Department of Electrical & Computer Engineering, University of Delaware
Kurt M. Schmoller: Institute of Functional Epigenetics, Helmholtz Zentrum München

DOI: https://doi.org/10.1038/s41467-021-24451-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Accurate regulation of protein concentrations according to changes in cell volume that accompany growth and changes in biosynthetic capacity is an important component of cellular homeostasis. Here, using the model organism S. cerevisiae, the authors show how histone production is quantitatively coupled to genome content through the intrinsic properties of histone promoters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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