Nature Communications (Feb 2017)

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

  • Sachin Hajarnis,
  • Ronak Lakhia,
  • Matanel Yheskel,
  • Darren Williams,
  • Mehran Sorourian,
  • Xueqing Liu,
  • Karam Aboudehen,
  • Shanrong Zhang,
  • Kara Kersjes,
  • Ryan Galasso,
  • Jian Li,
  • Vivek Kaimal,
  • Steven Lockton,
  • Scott Davis,
  • Andrea Flaten,
  • Joshua A. Johnson,
  • William L. Holland,
  • Christine M. Kusminski,
  • Philipp E. Scherer,
  • Peter C. Harris,
  • Marie Trudel,
  • Darren P. Wallace,
  • Peter Igarashi,
  • Edmund C. Lee,
  • John R. Androsavich,
  • Vishal Patel

DOI
https://doi.org/10.1038/ncomms14395
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions.