An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

Kenneth H. Gouin; Nathan Ing; Jasmine T. Plummer; Charles J. Rosser; Bassem Ben Cheikh; Catherine Oh; Stephanie S. Chen; Keith Syson Chan; Hideki Furuya; Warren G. Tourtellotte; Simon R. V. Knott; Dan Theodorescu

doi:10.1038/s41467-021-25103-7

Nature Communications (Aug 2021)

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

Kenneth H. Gouin,
Nathan Ing,
Jasmine T. Plummer,
Charles J. Rosser,
Bassem Ben Cheikh,
Catherine Oh,
Stephanie S. Chen,
Keith Syson Chan,
Hideki Furuya,
Warren G. Tourtellotte,
Simon R. V. Knott,
Dan Theodorescu

Affiliations

Kenneth H. Gouin: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Nathan Ing: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Jasmine T. Plummer: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Charles J. Rosser: Department of Surgery (Urology), Cedars-Sinai Medical Center
Bassem Ben Cheikh: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Catherine Oh: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Stephanie S. Chen: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Keith Syson Chan: Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute
Hideki Furuya: Department of Surgery (Urology), Cedars-Sinai Medical Center
Warren G. Tourtellotte: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Simon R. V. Knott: Department of Biomedical Sciences, Cedars-Sinai Medical Center
Dan Theodorescu: Department of Surgery (Urology), Cedars-Sinai Medical Center

DOI: https://doi.org/10.1038/s41467-021-25103-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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