State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China
Xianchun Gao
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China; Department of Health Statistics, Shaanxi Key Laboratory of Free Radical Biology and Medicine and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China
Jun Yu
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China
Shibo Wang
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China
Xishan Wang
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Kay Uehara
Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan
Yongzhan Nie
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China; Corresponding author.
Tumor deposits (TDs), initially recognized in colorectal cancer (CRC), have been identified in various other cancer types, including gastric cancer (GC), rendering them a widely studied adverse prognostic factor in gastrointestinal malignancies. They have implications for the tumor-node-metastasis (TNM) staging of CRC patients in specific contexts. This review discusses the definition, diagnosis, origin, and prognostic significance of TDs in CRC and GC patients. The incorporation of TDs into the TNM staging system is anticipated to enhance staging precision, which is very important for making appropriate treatment decisions. Nevertheless, the origins of TDs and their relationship with preoperative cancer therapies remain elusive, necessitating further investigation into this area.
