Nature Communications (May 2021)
The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
- Lei Chen,
- Shirley Luo,
- Abigail Dupre,
- Roshan P. Vasoya,
- Aditya Parthasarathy,
- Rohit Aita,
- Raj Malhotra,
- Joseph Hur,
- Natalie H. Toke,
- Eric Chiles,
- Min Yang,
- Weihuan Cao,
- Juan Flores,
- Christopher E. Ellison,
- Nan Gao,
- Amrik Sahota,
- Xiaoyang Su,
- Edward M. Bonder,
- Michael P. Verzi
Affiliations
- Lei Chen
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Shirley Luo
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Abigail Dupre
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Roshan P. Vasoya
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Aditya Parthasarathy
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Rohit Aita
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Raj Malhotra
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Joseph Hur
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Natalie H. Toke
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Eric Chiles
- Rutgers Cancer Institute of New Jersey, Rutgers University
- Min Yang
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Weihuan Cao
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Juan Flores
- Department of Biological Sciences, Rutgers University
- Christopher E. Ellison
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Nan Gao
- Department of Biological Sciences, Rutgers University
- Amrik Sahota
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- Xiaoyang Su
- Rutgers Cancer Institute of New Jersey, Rutgers University
- Edward M. Bonder
- Department of Biological Sciences, Rutgers University
- Michael P. Verzi
- Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University
- DOI
- https://doi.org/10.1038/s41467-021-22761-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin looping in these tissues between promoters and enhancers.
