Nature Communications (Nov 2018)
A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
- Lea B. S. Hansen,
- Henrik M. Roager,
- Nadja B. Søndertoft,
- Rikke J. Gøbel,
- Mette Kristensen,
- Mireia Vallès-Colomer,
- Sara Vieira-Silva,
- Sabine Ibrügger,
- Mads V. Lind,
- Rasmus B. Mærkedahl,
- Martin I. Bahl,
- Mia L. Madsen,
- Jesper Havelund,
- Gwen Falony,
- Inge Tetens,
- Trine Nielsen,
- Kristine H. Allin,
- Henrik L. Frandsen,
- Bolette Hartmann,
- Jens Juul Holst,
- Morten H. Sparholt,
- Jesper Holck,
- Andreas Blennow,
- Janne Marie Moll,
- Anne S. Meyer,
- Camilla Hoppe,
- Jørgen H. Poulsen,
- Vera Carvalho,
- Domenico Sagnelli,
- Marlene D. Dalgaard,
- Anders F. Christensen,
- Magnus Christian Lydolph,
- Alastair B. Ross,
- Silas Villas-Bôas,
- Susanne Brix,
- Thomas Sicheritz-Pontén,
- Karsten Buschard,
- Allan Linneberg,
- Jüri J. Rumessen,
- Claus T. Ekstrøm,
- Christian Ritz,
- Karsten Kristiansen,
- H. Bjørn Nielsen,
- Henrik Vestergaard,
- Nils J. Færgeman,
- Jeroen Raes,
- Hanne Frøkiær,
- Torben Hansen,
- Lotte Lauritzen,
- Ramneek Gupta,
- Tine Rask Licht,
- Oluf Pedersen
Affiliations
- Lea B. S. Hansen
- Department of Bio and Health Informatics, Technical University of Denmark
- Henrik M. Roager
- National Food Institute, Technical University of Denmark
- Nadja B. Søndertoft
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Rikke J. Gøbel
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Mette Kristensen
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Mireia Vallès-Colomer
- Department of Microbiology and Immunology, KU Leuven–University of Leuven, Rega Institute
- Sara Vieira-Silva
- Department of Microbiology and Immunology, KU Leuven–University of Leuven, Rega Institute
- Sabine Ibrügger
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Mads V. Lind
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Rasmus B. Mærkedahl
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Martin I. Bahl
- National Food Institute, Technical University of Denmark
- Mia L. Madsen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Jesper Havelund
- Department of Biochemistry and Molecular Biology, University of Southern Denmark
- Gwen Falony
- Department of Microbiology and Immunology, KU Leuven–University of Leuven, Rega Institute
- Inge Tetens
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Trine Nielsen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Kristine H. Allin
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Henrik L. Frandsen
- National Food Institute, Technical University of Denmark
- Bolette Hartmann
- Department of Biomedical Sciences, University of Copenhagen
- Jens Juul Holst
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Morten H. Sparholt
- Department of Radiology, Bispebjerg Hospital
- Jesper Holck
- Department of Chemical and Biochemical Engineering, Technical University of Denmark
- Andreas Blennow
- Department of Plant and Environmental Sciences, University of Copenhagen
- Janne Marie Moll
- Department of Biotechnology and Biomedicine, Technical University of Denmark
- Anne S. Meyer
- Department of Chemical and Biochemical Engineering, Technical University of Denmark
- Camilla Hoppe
- National Food Institute, Technical University of Denmark
- Jørgen H. Poulsen
- Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre
- Vera Carvalho
- National Food Institute, Technical University of Denmark
- Domenico Sagnelli
- Department of Plant and Environmental Sciences, University of Copenhagen
- Marlene D. Dalgaard
- Department of Biotechnology and Biomedicine, Technical University of Denmark
- Anders F. Christensen
- Department of Radiology, Bispebjerg Hospital
- Magnus Christian Lydolph
- Department of Autoimmunology & Biomarkers, Statens Serum Institut
- Alastair B. Ross
- Department of Biology and Biological Engineering, Chalmers University of Technology
- Silas Villas-Bôas
- School of Biological Sciences, The University of Auckland
- Susanne Brix
- Department of Biotechnology and Biomedicine, Technical University of Denmark
- Thomas Sicheritz-Pontén
- Department of Bio and Health Informatics, Technical University of Denmark
- Karsten Buschard
- Bartholin Institute, Rigshospitalet
- Allan Linneberg
- Research Centre for Prevention and Health, The Capital Region of Denmark
- Jüri J. Rumessen
- Research Unit and Department of Gastroenterology, Herlev and Gentofte Hospital, the Capital Region of Denmark
- Claus T. Ekstrøm
- Biostatistics, Department of Public Health, University of Copenhagen
- Christian Ritz
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Karsten Kristiansen
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen
- H. Bjørn Nielsen
- Clinical-Microbiomics A/S
- Henrik Vestergaard
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Nils J. Færgeman
- Department of Biochemistry and Molecular Biology, University of Southern Denmark
- Jeroen Raes
- Department of Microbiology and Immunology, KU Leuven–University of Leuven, Rega Institute
- Hanne Frøkiær
- Department of Veterinary Disease Biology, Faculty of Science, University of Copenhagen
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- Lotte Lauritzen
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Ramneek Gupta
- Department of Bio and Health Informatics, Technical University of Denmark
- Tine Rask Licht
- National Food Institute, Technical University of Denmark
- Oluf Pedersen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-018-07019-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Gluten-free diets are increasingly common in the general population. Here, the authors report the results of a randomised cross-over trial involving middle-aged, healthy Danish adults, showing evidence that a low-gluten diet leads to gut microbiome changes, possibly due to variations in dietary fibres.
