Immunohistochemical study of MUC5AC, MUC1, MUC2, Cdx-2 in hyperplastic polyps and intestinal-type gastric adenocarcinoma

Zaporožskij Medicinskij Žurnal. 2017;(5):629-636 DOI 10.14739/2310-1210.2017.5.110170

 

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Journal Title: Zaporožskij Medicinskij Žurnal

ISSN: 2306-4145 (Print); 2310-1210 (Online)

Publisher: Zaporozhye State Medical University

Society/Institution: Zaporozhye State Medical University

LCC Subject Category: Medicine

Country of publisher: Ukraine

Language of fulltext: Ukrainian, English, Russian

Full-text formats available: PDF

 

AUTHORS

V. A. Tumanskiy
T. A. Khrystenko

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text

Aim – to study the features of MUC1, MUC2, MUC5AC, Cdx-2 immunohistochemical expression in hyperplastic polyps and intestinal-type gastric adenocarcinoma, and their relationships with the proliferation and apoptosis markers expression levels, EGFR and HER-2/neu growth receptors. Materials and мethods. Pathomorphological and immunohistochemical studies of hyperplastic polyps from 30 patients (the age ranged from 52 to 73 years) and intestinal-type gastric adenocarcinoma from 30 patients (the age ranged from 49 to 86 years) were carried out. Results. It has been established that the gastric hyperplastic polyps are characterized by the high MUC5AC expression level, the moderate MUC1expression level, as well as the low MUC2 and Cdx-2 expression levels. The tumor cells of the intestinal-type gastric adenocarcinoma express gastric mucins less often, and are characterized by the moderate expression levels of the examined markers. In doing so, the carcinoma is characterized by the inverse correlations between gastric and intestinal mucins expression levels, and also by the correlations between the mucins markers expression levels and the histological grade of the tumor. It has been found, that the decrease in the MUC1 expression level by the tumor cells is associated with the increase in their proliferative level, while the decrease in the MUC1 and MUC5AC expression levels – with the decrease in their apoptosis level and also with the increase in the ErbB family growth receptors expression levels by the tumor cells. In addition, the increase in MUC2 expression level is associated with the decrease in apoptosis level, while the increase in the MUC2 and Cdx-2 expression levels – with the increase in EGFR expression level. Conclusions. There are close relationships between MUC1, MUC2, MUC5AC, Cdx-2 immunohistochemical expression levels and the levels of proliferative and apoptotic activity of intestinal-type gastric adenocarcinoma tumor cells, and also their expression of ErbB growth receptors. stomach neoplasms; polyps; adenocarcinoma; mucins; CDX2 transcription factor