Nature Communications (Nov 2017)
Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
- Gregorio Iraola,
- Samuel C. Forster,
- Nitin Kumar,
- Philippe Lehours,
- Sadjia Bekal,
- Francisco J. García-Peña,
- Fernando Paolicchi,
- Claudia Morsella,
- Helmut Hotzel,
- Po-Ren Hsueh,
- Ana Vidal,
- Simon Lévesque,
- Wataru Yamazaki,
- Claudia Balzan,
- Agueda Vargas,
- Alessandra Piccirillo,
- Bonnie Chaban,
- Janet E. Hill,
- Laura Betancor,
- Luis Collado,
- Isabelle Truyers,
- Anne C. Midwinter,
- Hatice T. Dagi,
- Francis Mégraud,
- Lucía Calleros,
- Ruben Pérez,
- Hugo Naya,
- Trevor D. Lawley
Affiliations
- Gregorio Iraola
- Unidad de Bioinformática, Institut Pasteur Montevideo
- Samuel C. Forster
- Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute
- Nitin Kumar
- Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute
- Philippe Lehours
- Bordeaux Research in Translational Oncology, INSERM UMR1053, University of Bordeaux
- Sadjia Bekal
- Laboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec
- Francisco J. García-Peña
- Departamento de Bacteriología, Laboratorio Central de Veterinaria de Algete (MAGRAMA)
- Fernando Paolicchi
- Laboratorio de Bacteriología, EEA-INTA Balcarce
- Claudia Morsella
- Laboratorio de Bacteriología, EEA-INTA Balcarce
- Helmut Hotzel
- Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses
- Po-Ren Hsueh
- Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital
- Ana Vidal
- Animal and Plant Health Association (APHA)
- Simon Lévesque
- Laboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec
- Wataru Yamazaki
- Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
- Claudia Balzan
- Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria
- Agueda Vargas
- Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria
- Alessandra Piccirillo
- Department of Comparative Biomedicine and Food Science, University of Padova
- Bonnie Chaban
- Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast
- Janet E. Hill
- Department of Veterinary Microbiology, University of Saskatchewan
- Laura Betancor
- Instituto de Higiene, Facultad de Medicina, Universidad de la República
- Luis Collado
- Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile
- Isabelle Truyers
- Royal (Dick) School of Veterinary Studies, University of Edinburgh
- Anne C. Midwinter
- EpiLab, Infectious Disease Research Centre, Massey University
- Hatice T. Dagi
- Department of Microbiology, Faculty of Medicine, Selçuk University
- Francis Mégraud
- Bordeaux Research in Translational Oncology, INSERM UMR1053, University of Bordeaux
- Lucía Calleros
- Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República
- Ruben Pérez
- Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República
- Hugo Naya
- Unidad de Bioinformática, Institut Pasteur Montevideo
- Trevor D. Lawley
- Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-017-01449-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Human infections with Campylobacter fetus are often assumed to be derived from livestock. Here, Iraola et al. provide evidence that healthy humans may act as carriers and dispersers, and C. fetus may have originated in humans as an intestinal pathobiont and then adapted as a livestock pathogen.
