Communications Biology (Jul 2021)

A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

  • Xiaoan Wu,
  • Marta E. Perez,
  • Sergei Yu Noskov,
  • H. Peter Larsson

DOI
https://doi.org/10.1038/s42003-021-02418-1
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur that prohibit the formation of a conductive intermediate state conformation of the voltage sensor.