mBio (Jun 2021)

Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment

  • Tiffany Russell,
  • Jerzy Samolej,
  • Michael Hollinshead,
  • Geoffrey L. Smith,
  • Joanne Kite,
  • Gillian Elliott

DOI
https://doi.org/10.1128/mBio.02183-20
Journal volume & issue
Vol. 12, no. 3

Abstract

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Cellular transport pathways play a fundamental role in secretion and membrane biogenesis. Enveloped viruses exploit these pathways to direct their membrane proteins to sites of envelopment and, as such, are powerful tools for unraveling subtle activities of trafficking factors, potentially pinpointing therapeutic targets.