Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment

Tiffany Russell; Jerzy Samolej; Michael Hollinshead; Geoffrey L. Smith; Joanne Kite; Gillian Elliott

doi:10.1128/mBio.02183-20

mBio (Jun 2021)

Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment

Tiffany Russell,
Jerzy Samolej,
Michael Hollinshead,
Geoffrey L. Smith,
Joanne Kite,
Gillian Elliott

Affiliations

Tiffany Russell: Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom
Jerzy Samolej: Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom
Michael Hollinshead: Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Geoffrey L. Smith: Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Joanne Kite: Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom
Gillian Elliott: ORCiD; Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom

DOI: https://doi.org/10.1128/mBio.02183-20
Journal volume & issue: Vol. 12, no. 3

Abstract

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Cellular transport pathways play a fundamental role in secretion and membrane biogenesis. Enveloped viruses exploit these pathways to direct their membrane proteins to sites of envelopment and, as such, are powerful tools for unraveling subtle activities of trafficking factors, potentially pinpointing therapeutic targets.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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