A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction

Abstract

Summary: Here, we present a robust protocol for the facile and rapid synthesis of functionalized secondary amines in continuous flow. More specifically, we describe a detailed guide to perform a photocatalyzed Petasis reaction within 50 min using alkyl boronic acid as radical precursor and a Vapourtec E-series as key equipment. The desired functionalized amine has been synthesized in mmol scale and with a productivity rate of 0.2 mmol/h. The protocol is limited to alkyl boronic acids.For complete details on the generation and use of this protocol, please refer to Oliva et al. (2021).

Keywords

• Chemistry
• Environmental sciences