Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

Abstract

In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates H3 and H2B, but has also been implicated in global H4 deacetylation. Here, the authors provide evidence that Hda1C binds to hyperactive genes, where it specifically deacetylates H4 to partially inhibit elongation, suggesting a role for Hda1C in elongation by specifically deacetylating H4 at highly transcribed regions.