Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics

Abstract

Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of Aβ-peptides.

Keywords

• β-lactam antibiotics
• acetylcholinesterase
• amyloid beta peptides
• butyrylcholinesterase
• molecular docking
• β-laktam antibiyotik
• amiloid beta peptit
• asetilkolinesteraz
• bütirilkolinesteraz
• moleküler modelleme