Communications Biology (Sep 2022)
Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats
- Haruki Nishimura,
- Mitsuhiro Yoshimura,
- Makiko Shimizu,
- Kenya Sanada,
- Satomi Sonoda,
- Kazuaki Nishimura,
- Kazuhiko Baba,
- Naofumi Ikeda,
- Yasuhito Motojima,
- Takashi Maruyama,
- Yuki Nonaka,
- Ryoko Baba,
- Tatsushi Onaka,
- Takafumi Horishita,
- Hiroyuki Morimoto,
- Yasuhiro Yoshida,
- Makoto Kawasaki,
- Akinori Sakai,
- Masafumi Muratani,
- Becky Conway-Campbell,
- Stafford Lightman,
- Yoichi Ueta
Affiliations
- Haruki Nishimura
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Mitsuhiro Yoshimura
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Makiko Shimizu
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Kenya Sanada
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Satomi Sonoda
- The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
- Kazuaki Nishimura
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Kazuhiko Baba
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Naofumi Ikeda
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Yasuhito Motojima
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
- Takashi Maruyama
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Yuki Nonaka
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- Ryoko Baba
- Department of Anatomy (II), School of Medicine, University of Occupational and Environmental Health
- Tatsushi Onaka
- Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University
- Takafumi Horishita
- Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health
- Hiroyuki Morimoto
- Department of Anatomy (II), School of Medicine, University of Occupational and Environmental Health
- Yasuhiro Yoshida
- Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health
- Makoto Kawasaki
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
- Akinori Sakai
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
- Masafumi Muratani
- Genome Biology, Faculty of Medicine, University of Tsukuba
- Becky Conway-Campbell
- Translational Health Sciences, Bristol Medical School, University of Bristol
- Stafford Lightman
- Translational Health Sciences, Bristol Medical School, University of Bristol
- Yoichi Ueta
- Department of Physiology, School of Medicine, University of Occupational and Environmental Health
- DOI
- https://doi.org/10.1038/s42003-022-03879-8
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 19
Abstract
The analgesic effect of oxytocin appears to be mediated via an oxytocin receptor and endogenous oxytocin contributes to the anti-nociception and anti-inflammatory response.
