Nature Communications (Dec 2018)

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

  • Heuijoon Park,
  • Sonali Lad,
  • Kelsey Boland,
  • Kelly Johnson,
  • Nyssa Readio,
  • Guangchun Jin,
  • Samuel Asfaha,
  • Kelly S. Patterson,
  • Ashok Singh,
  • Xiangdong Yang,
  • Douglas Londono,
  • Anupama Singh,
  • Carol Trempus,
  • Derek Gordon,
  • Timothy C. Wang,
  • Rebecca J. Morris

DOI
https://doi.org/10.1038/s41467-018-07688-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Bone marrow-derived epithelial cells can be recruited to sites of chronic inflammation. Here, the authors using allogenic bone marrow transplantation in a multistage murine cutaneous carcinogenesis model show that bone marrow-derived epithelial cells and hair follicle stem cells are recruited to cutaneous neoplasms during tumor promotion of carcinogen-exposed skin and bone marrow.