Stereoselective Total Synthesis of Macrolide Sch-725674 and C-7-epi-Sch-725674

Abstract

Abstract The stereoselective total synthesis of Sch-725674 in 14 ­linear synthetic steps with 10.3% overall yield is described. The synthesis started from commercially available starting materials, d-ribose and (R)-benzyl glycidol. The key reactions involved CBS reduction, Julia–­Kocienski olefination, Horner–Wadsworth–Emmons reaction, and ­Shiina macrolactonization.

Keywords

• natural product synthesis
• macrolides
• sch-725674
• c-7-epi-sch-725674
• antifungal agents