Nature Communications (Jan 2022)
Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia
- Álvaro Andreu-Bernabeu,
- Covadonga M. Díaz-Caneja,
- Javier Costas,
- Lucía De Hoyos,
- Carol Stella,
- Xaquín Gurriarán,
- Clara Alloza,
- Lourdes Fañanás,
- Julio Bobes,
- Ana González-Pinto,
- Benedicto Crespo-Facorro,
- Lourdes Martorell,
- Elisabet Vilella,
- Gerard Muntané,
- Juan Nacher,
- María Dolores Molto,
- Eduardo Jesús Aguilar,
- Mara Parellada,
- Celso Arango,
- Javier González-Peñas
Affiliations
- Álvaro Andreu-Bernabeu
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Covadonga M. Díaz-Caneja
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Javier Costas
- Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saúde (SERGAS), Santiago de Compostela
- Lucía De Hoyos
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Carol Stella
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Xaquín Gurriarán
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Clara Alloza
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Lourdes Fañanás
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Julio Bobes
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Ana González-Pinto
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Benedicto Crespo-Facorro
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Lourdes Martorell
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Elisabet Vilella
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Gerard Muntané
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Juan Nacher
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- María Dolores Molto
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Eduardo Jesús Aguilar
- CIBERSAM, Centro Investigación Biomédica en Red Salud Mental
- Mara Parellada
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Celso Arango
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- Javier González-Peñas
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón
- DOI
- https://doi.org/10.1038/s41467-021-27598-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Loneliness and social isolation (LNL-ISO) are associated with schizophrenia. Here the authors demonstrate the role of shared heritability, bidirectional causal relationships and significant differences by sex, illustrating the genomic footprint of social isolation on schizophrenia.
