Epigenetic targeting for lung cancer treatment via CRISPR/Cas9 technology

Abstract

The growth of CRISPR/Cas9 system and findings of various Cas9 protein forms along with its improved delivery methodologies has enhanced the practical applications of gene editing. Inducing desired gene of interest to correcting disease related mutations and to suppress or activate a gene of interest efficiently is now practically possible with the help CRISPR/Cas9 system. The main cause of lung cancer is the dysregulation of epigenetic markers which bring transformation in normal cells. Targeting epigenetic modification or epigenetic regulatory enzymes with the help of CRISPR/Cas9 system might be a vital step for cancer therapy.

Keywords

• Oncogene
• dCas9
• Lung cancer
• Tumor suppressor genes
• CRISPR/Cas9