Nature Communications (Nov 2016)
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
Abstract
Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.