Nature Communications (Nov 2016)

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

  • Martijn H. den Brok,
  • Christian Büll,
  • Melissa Wassink,
  • Annemarie M. de Graaf,
  • Jori A. Wagenaars,
  • Marthe Minderman,
  • Mayank Thakur,
  • Sebastian Amigorena,
  • Eric O. Rijke,
  • Carla C. Schrier,
  • Gosse J. Adema

DOI
https://doi.org/10.1038/ncomms13324
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.