Frontiers in Public Health (Apr 2022)
A Nomogram for Predicting Cancer-Specific Survival in Children With Wilms Tumor: A Study Based on SEER Database and External Validation in China
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Xiaojun Tan,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jinkui Wang,
- Jie Tang,
- Xiaomao Tian,
- Xiaomao Tian,
- Xiaomao Tian,
- Xiaomao Tian,
- Xiaomao Tian,
- Xiaomao Tian,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Liming Jin,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Mujie Li,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Zhaoxia Zhang,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He,
- Dawei He
Affiliations
- Xiaojun Tan
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Xiaojun Tan
- Department of Urology, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical University, Nanchong, China
- Xiaojun Tan
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Xiaojun Tan
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Xiaojun Tan
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Xiaojun Tan
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Xiaojun Tan
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Jinkui Wang
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Jinkui Wang
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Jinkui Wang
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Jinkui Wang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Jinkui Wang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Jinkui Wang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Jie Tang
- Department of Epidemiology, Public Health School, Shenyang Medical College, Shenyang, China
- Xiaomao Tian
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Xiaomao Tian
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Xiaomao Tian
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Xiaomao Tian
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Xiaomao Tian
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Xiaomao Tian
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Liming Jin
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Liming Jin
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Liming Jin
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Liming Jin
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Liming Jin
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Liming Jin
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Mujie Li
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Mujie Li
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Mujie Li
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Mujie Li
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Mujie Li
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Mujie Li
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Zhaoxia Zhang
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Zhaoxia Zhang
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Zhaoxia Zhang
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Zhaoxia Zhang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Zhaoxia Zhang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Zhaoxia Zhang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Dawei He
- Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China
- Dawei He
- Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China
- Dawei He
- Chongqing Key Laboratory of Pediatrics, Chongqing, China
- Dawei He
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Dawei He
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Dawei He
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- DOI
- https://doi.org/10.3389/fpubh.2022.829840
- Journal volume & issue
-
Vol. 10
Abstract
BackgroundWilms tumor (WT) is the most common tumor in children. We aim to construct a nomogram to predict the cancer-specific survival (CSS) of WT in children and externally validate in China.MethodsWe downloaded the clinicopathological data of children with WT from 2004 to 2018 in the SEER database. At the same time, we used the clinicopathological data collected previously for all children with WT between 2013 and 2018 at Children's Hospital of Chongqing Medical University (Chongqing, China). We analyzed the difference in survival between the patients in the SEER database and our hospital. Cox regression analysis was used to screen for significant risk factors. Based on these factors, a nomogram was constructed to predict the CSS of children with WT. Calibration curve, concordance index (C-index), the area under the receiver operating curve (AUC) and decision curve analysis (DCA) was used to evaluate the accuracy and reliability of the model.ResultsWe included 1,045 children with WT in the SEER database. At the same time, we collected 112 children with WT in our hospital. The Kaplan-Meier curve suggested that children in China with WT had a higher mortality rate than those in the United States. Cox regression analysis revealed that age, lymph node density (LND), and tumor stage were significant prognostic factors for the patients in the SEER database. However, the patients in our hospital only confirmed that the tumor stage and the number of positive regional lymph nodes were significant factors. The prediction model established by the SEER database had been validated internally and externally to prove that it had good accuracy and reliability.ConclusionWe have constructed a survival prognosis prediction model for children with WT, which has been validated internally and externally to prove accuracy and reliability.
Keywords
