A Causal Relationship between Type 2 Diabetes and Candidiasis through Two-Sample Mendelian Randomization Analysis

Abstract

The potential relationship between type 2 diabetes (T2D) and candidiasis is of concern due to the respective characteristics of these conditions, yet the exact causal link between the two remains uncertain and requires further investigation. In this study, the inverse-variance-weighted (IVW) analysis indicated a significant genetic causal relationship between T2D and candidiasis (p = 0.0264, Odds Ratio [OR], 95% confidence interval [CI] = 1.1046 [0.9096–1.2996]), T2D (wide definition) and candidiasis (p = 0.0031, OR 95% [CI] = 1.1562 [0.8718–1.4406]), and severe autoimmune T2D and candidiasis (p = 0.0041, OR 95% [CI] = 1.0559 [0.9493–1.1625]). Additionally, the MR-Egger analyses showed a significant genetic causal relationship between T2D (wide definition) and candidiasis (p = 0.0154, OR 95% [CI] = 1.3197 [0.7760–1.8634]). The weighted median analyses showed a significant genetic causal relationship between severe autoimmune T2D and candidiasis (p = 0.0285, OR 95% [CI] = 1.0554 [0.9498–1.1610]). This Mendelian randomization (MR) study provides evidence for a genetic correlation between T2D and candidiasis.

Keywords

• type 2 diabetes
• candidiasis
• genetic causal relationship
• Mendelian randomization