Cell Reports (Aug 2021)
The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life
- Miriam A. Lynn,
- Georgina Eden,
- Feargal J. Ryan,
- Julien Bensalem,
- Xuemin Wang,
- Stephen J. Blake,
- Jocelyn M. Choo,
- Yee Tee Chern,
- Anastasia Sribnaia,
- Jane James,
- Saoirse C. Benson,
- Lauren Sandeman,
- Jianling Xie,
- Sofia Hassiotis,
- Emily W. Sun,
- Alyce M. Martin,
- Marianne D. Keller,
- Damien J. Keating,
- Timothy J. Sargeant,
- Christopher G. Proud,
- Steve L. Wesselingh,
- Geraint B. Rogers,
- David J. Lynn
Affiliations
- Miriam A. Lynn
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Georgina Eden
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Feargal J. Ryan
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Julien Bensalem
- Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Xuemin Wang
- Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, SA 5000, Australia; School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia
- Stephen J. Blake
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Jocelyn M. Choo
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- Yee Tee Chern
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Anastasia Sribnaia
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Jane James
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Saoirse C. Benson
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- Lauren Sandeman
- Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, SA 5000, Australia
- Jianling Xie
- Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, SA 5000, Australia
- Sofia Hassiotis
- Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Emily W. Sun
- Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- Alyce M. Martin
- Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- Marianne D. Keller
- Preclinical, Imaging & Research Laboratories (PIRL), South Australian Health & Medical Research Institute, Adelaide, SA 5000, Australia
- Damien J. Keating
- Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- Timothy J. Sargeant
- Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
- Christopher G. Proud
- Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, SA 5000, Australia; School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia
- Steve L. Wesselingh
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- Geraint B. Rogers
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia
- David J. Lynn
- Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia; Corresponding author
- Journal volume & issue
-
Vol. 36,
no. 8
p. 109564
Abstract
Summary: Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.
