ImmunoTargets and Therapy (Jan 2024)
CD69 is a Promising Immunotherapy and Prognosis Prediction Target in Cancer
Abstract
Yuchen Li,1,* Yinfeng Gu,1,* Pengyue Yang,1 Yan Wang,1 Xibao Yu,1 Yangqiu Li,1 Zhenyi Jin,1,2 Ling Xu1,3 1Institute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, People’s Republic of China; 2Department of Pathology, School of Medicine, Jinan University, Guangzhou, 510632, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, 510632, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Xu; Zhenyi Jin, Email [email protected]; [email protected]: Immunotherapy utilizing T cells that attack tumors is a promising strategy for treatment, but immune suppressive T cell subsets, such as regulatory T cell (Treg), and immune checkpoint molecules, including programmed death-1 (PD-1), can suppress the intensity of a T cell immune reaction and thereby impair tumor clearance. Cluster of differentiation 69 (CD69), known as an early leukocyte activation marker, can be used as a measure or early marker of T cell activation. In recent years, the functions of CD69 in the regulation of Treg/Th17 (T helper cell 17) differentiation and in the tissue retention of T cells have attracted considerable interest. These functions are related to the role of CD69 in immune suppression in tumor environments (TME). In this review, we first summarized current perspectives in the biological function of CD69 and demonstrated that CD69 acts as a regulator of T cell activation, differentiation, retention, and exhaustion. Then, we discussed recent advances in understanding of CD69 deficiency and anti-CD69 antibody administration and shed light on the value of targeting on CD69 for cancer immunotherapy and prognosis prediction.Keywords: CD69, T cell, immunotherapy
