Antimicrobial Resistance and Infection Control (Apr 2021)

Carriage of two carbapenem-resistance genes in Pseudomonas aeruginosa isolated from hospital-acquired infections in children from Costa Rica: the importance of local epidemiology

  • Cristian Pérez-Corrales,
  • Valeria Peralta-Barquero,
  • Christopher Mairena-Acuña

DOI
https://doi.org/10.1186/s13756-021-00942-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 3

Abstract

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Abstract Background The assessment of Hospital-acquired infections due to multidrug-resistant bacteria involves the use of a variety of commercial and laboratory-developed tests to detect antimicrobial resistance genes in bacterial pathogens; however, few are evaluated for use in low- and middle-income countries. Methods We used whole-genome sequencing, rapid commercial molecular tests, laboratory-developed tests and routine culture testing. Results We identified the carriage of the metallo-β-lactamase bla VIM-2 and bla IMP-18 alleles in Carbapenem-Resistant Pseudomonas aeruginosa infections among children in Costa Rica. Conclusions The bla IMP-18 allele is not present in the most frequently used commercial tests; thus, it is possible that the circulation of this resistance gene may be underdiagnosed in Costa Rica.

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